Where else but MDLinx OB/GYN can you find all the literature published in over 2,000 top peer-reviewed medical journals, ranked and summarized for you every 24 hours? Our team of physician editors is dedicated to keeping you current in less than 5 minutes a day. We cover the entirety of your diverse specialty, with subspecialty topics chosen to address the information needs of the entire women’s healthcare team, including gynecologic oncology, maternal-fetal medicine, obstetric and gynecologic surgery, ped/adolescent gynecology, repro/endo and infertility, the breast, menopausal medicine, diagnostic imaging, and much more.
Also find bonus content on this page that includes articles highlighted by our physician editor, D. Scott Cunningham, MD, PhD, that are “must-read.” Additionally, because Maintenance of Certification (MOC) is always a concern, we will provide some of the recent clinical pearls related to Obstetrics & Gynecology from our Smartest Doc and Physician Review quizzes, many of which result from a collaboration with the Cleveland Clinic Center for Continuing Education.
Your Unread Messages in Obstetrics & Gynecology
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D Scott Cunningham MD, PhD
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UAE more effective than myomectomy for leiomyomas
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1 Lumpectomy plus tamoxifen with or without irradiation in women age 70 years or older with early breast cancer: long-term follow-up of calgb 9343 Journal of Clinical Oncology, May 24, 2013 Clinical Article
2 Paclitaxel, carboplatin, and trastuzumab in a neo-adjuvant regimen for her2-positive breast cancer The Breast Journal, May 24, 2013 Clinical Article
3 An open-label safety study of lapatinib plus trastuzumab plus paclitaxel in first-line HER2-positive metastatic breast cancer Full Text The Oncologist, May 24, 2013 Clinical Article
4 Clinical and genetic determinants of plasma nevirapine exposure following an intrapartum dose to prevent mother-to-child transmission The Journal of Infectious Diseases, May 24, 2013 Clinical Article
5 Haemodynamic effects of glycopyrrolate pre-treatment before phenylephrine infusion during spinal anaesthesia for caesarean delivery International Journal of Obstetric Anesthesia , May 24, 2013 Clinical Article
6 Transcutaneous carbon dioxide levels and oxygen saturation following caesarean section performed under spinal anaesthesia with intrathecal opioids International Journal of Obstetric Anesthesia , May 24, 2013 Clinical Article
7 Atazanavir pharmacokinetics, efficacy and safety in pregnancy: a systematic review Antiviral Therapy , May 23, 2013 Review Article Clinical Article
8 Effects of drospirenone–ethinylestradiol and/or metformin on CD4+CD28null t lymphocytes frequency in women with hyperinsulinemia having polycystic ovary syndrome: A randomized clinical trial Reproductive Sciences, May 23, 2013 Clinical Article
9 Comparison of the efficacy of dexmedetomidine plus fentanyl patient-controlled analgesia with fentanyl patient-controlled analgesia for pain control in uterine artery embolization for symptomatic fibroid tumors or adenomyosis: a prospective, randomized study Journal of Vascular and Interventional Radiology, May 23, 2013 Clinical Article
10 Preconceptional low-dose aspirin for the prevention of hypertensive pregnancy complications and preterm delivery after IVF: a meta-analysis with individual patient data Human Reproduction, May 22, 2013 Clinical Article
11 Is a Dexamethasone-Sparing Strategy Capable of Preventing Acute and Delayed Emesis Caused by Combined Doxorubicin and Paclitaxel for Breast Cancer? Analysis of a Phase II Trial Oncology, May 22, 2013 Clinical Article
12 Neoadjuvant rh-endostatin, docetaxel and epirubicin for breast cancer: efficacy and safety in a prospective, randomized, phase II study Full Text BMC Cancer, May 22, 2013 Clinical Article
13 Rank-based predictors for response and prognosis of neoadjuvant taxane-anthracycline-based chemotherapy in breast cancer Breast Cancer Research and Treatment, May 22, 2013 Clinical Article
14 Improved dosage form of the combined alendronate and calcitriol (Maxmarvil) on the absorption of alendronate in Korean postmenopausal women Full Text Archives of Pharmacal Research, May 21, 2013 Review Article
15 Influence of CYP2D6-genotype on tamoxifen efficacy in advanced breast cancer Breast Cancer Research and Treatment, May 21, 2013 Clinical Article
16 Randomized controlled trial of toremifene 120 mg compared with exemestane 25 mg after prior treatment with a non-steroidal aromatase inhibitor in postmenopausal women with hormone receptor-positive metastatic breast cancer Full Text BMC Cancer, May 20, 2013 Clinical Article
17 Phase I dose-escalation study and population pharmacokinetic analysis of fixed dose rate gemcitabine plus carboplatin as second-line therapy in patients with ovarian cancer Gynecologic Oncology, May 20, 2013 Clinical Article
18 Phase II study of temsirolimus (CCI-779) in women with recurrent, unresectable, locally advanced or metastatic carcinoma of the cervix. a trial of the NCIC clinical trials group (NCIC CTG IND 199) Gynecologic Oncology, May 20, 2013 Clinical Article
19 Loss of dok2 induces carboplatin resistance in ovarian cancer via suppression of apoptosis Gynecologic Oncology, May 20, 2013 Clinical Article
20 Cognitive function in older women with breast cancer treated with standard chemotherapy and capecitabine on Cancer and Leukemia Group B 49907 Breast Cancer Research and Treatment, May 20, 2013 Clinical Article
Based on a review article published in BMC Infectious Diseases, it has been concluded that antiseptics have equal efficacy to antibiotics in the treatment of bacterial vaginosis. The literature search covered the time period 1966-2010. Benzydamine, chlorhexidine, and polyhexamethylene niguanide were as effective as metronidazole and clindamycin in the short-term treatment of bacterial vaginosis.
Read the article summaryBased on an observational study orchestrated by researchers at the M D Anderson Cancer Center, BRCA2 mutations have been associated with improved survival in patients with high-grade serous ovarian cancer. The 5-year OS in patients with BRCA2 mutations was 61% compared with 25% for patients with BRCA wild-type. The 3-year PFS in patients with BRCA2 mutations was 44% compared with 16% for patients with BRCA wild-type. Patients with BRCA2 mutations exhibited 100% chemosensitivity compared to 82% and 80% for patients with BRCA wild-type and BRCA1 mutations, respectively. Genomic analysis of the tumors from patients with BRCA2 mutations suggested a “mutator phenotype” compared to tumors from patients with BRCA1 mutations.
Read the article summaryIn a study involving 87,025 postmenopausal women, those in the highest quintile of dietary trans fat had an increased risk of ischemic stroke (HR=1.39). In 663,041 person-years of follow-up, 1049 incident cases of ischemic stroke were reported. The effect was attenuated in aspirin users (HR=0.95) compared to non-users (HR=1.66).
Read the article summary1 Prevention of preterm birth by progestational agents: what are the molecular mechanisms? American Journal of Obstetrics and Gynecology, February 25, 2013
2 Relapse of endometrial hyperplasia after conservative treatment: a cohort study with long-term follow-up Human Reproduction, March 14, 2013
3 Preconceptional low-dose aspirin for the prevention of hypertensive pregnancy complications and preterm delivery after IVF: a meta-analysis with individual patient data Human Reproduction, March 28, 2013 Evidence Based Medicine Review Article
4 Recent advances in the management of major obstetric haemorrhage British Journal of Medical Practitioners, April 2, 2013 Free full text
5 Women with pre-existing diabetes under the care of diabetes specialist prior to pregnancy: are their outcomes better? Australian and New Zealand Journal of Obstetrics and Gynaecology, March 6, 2013
6 Labor Induction for Premature Rupture of Membranes Using Vaginal Misoprostol versus Dinoprostone Vaginal Insert American Journal of Perinatology, April 18, 2013
7 Is there a role for progesterone in the management of acute organophosphate poisoning during pregnancy? Medical Hypotheses, April 9, 2013
8 Management of Vulvovaginal Lichen Planus: A New Approach Journal of Lower Genital Tract Disease, March 12, 2013
9 The basic fertility workup in women with polycystic ovary syndrome: a systematic review Fertility and Sterility, April 17, 2013 Evidence Based Medicine Review Article
10 What is in our environment that effects puberty? Reproductive Toxicology, April 22, 2013 Review Article
11 The Use of Aromatase Inhibitors for Ovulation Induction and Superovulation Journal of Clinical Endocrinology and Metabolism, April 17, 2013 Review Article
12 Pregnancy outcomes following gabapentin use: Results of a prospective comparative cohort study Neurology, April 8, 2013
13 Single dose oral ibuprofen plus codeine for acute postoperative pain in adults Cochrane Reviews, April 1, 2013 Review Article
14 A First Look at Chorioamnionitis Management Practice Variation among US Obstetricians Infectious Diseases in Obstetrics and Gynecology, February 11, 2013 Free full text
15 Does 17-alpha-hydroxyprogesterone caproate affect fetal biometry and birth weight? Ultrasound in Obstetrics & Gynecology, April 25, 2013
16 Neonatal Outcomes After Gestational Exposure to Nitrofurantoin Obstetrics and Gynecology, February 21, 2013
17 Methylphenidate use in pregnancy and lactation, a systematic review of evidence. British Journal of Clinical Pharmacology, April 22, 2013
18 Postpartum haemorhage associated with caesarean section and caesarean hysterectomy Best Practice & Research Clinical Obstetrics & Gynaecology, March 11, 2013
19 Methods of term labour induction for women with a previous caesarean section Cochrane Reviews, April 1, 2013 Review Article
20 The Rebirth of Progesterone in the Prevention of Preterm Labor Annals of Pharmacotherapy, March 28, 2013
Indexed Journals in Obstetrics & Gynecology: Obstetrics and Gynecology, American Journal of Obstetrics and Gynecology more
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