Where else but MDLinx OB/GYN can you find all the literature published in over 2,000 top peer-reviewed medical journals, ranked and summarized for you every 24 hours? Our team of physician editors is dedicated to keeping you current in less than 5 minutes a day. We cover the entirety of your diverse specialty, with subspecialty topics chosen to address the information needs of the entire women’s healthcare team, including gynecologic oncology, maternal-fetal medicine, obstetric and gynecologic surgery, ped/adolescent gynecology, repro/endo and infertility, the breast, menopausal medicine, diagnostic imaging, and much more.
Also find bonus content on this page that includes articles highlighted by our physician editor, D. Scott Cunningham, MD, PhD, that are “must-read.” Additionally, because Maintenance of Certification (MOC) is always a concern, we will provide some of the recent clinical pearls related to Obstetrics & Gynecology from our Smartest Doc and Physician Review quizzes, many of which result from a collaboration with the Cleveland Clinic Center for Continuing Education.
Your Unread Messages in Obstetrics & Gynecology
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D Scott Cunningham MD, PhD
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UAE more effective than myomectomy for leiomyomas
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Running from that pile of unread journals?
121 Duloxetine for major depressive disorder and daytime and nighttime hot flashes associated with the menopausal transition Maturitas, April 10, 2013 Clinical Article
122 Intracranial KCL injection - An alternative method for multifetal pregnancy reduction in the early second trimester Fetal Diagnosis and Therapy, April 10, 2013 Clinical Article
123 An Update on Developments in Female Hormonal Contraception Current Women’s Health Reviews, April 10, 2013 Clinical Article
124 A pilot feasibility study for cisplatin plus S-1 for the treatment for advanced or recurrent cervical cancer Cancer Chemotherapy and Pharmacology, April 10, 2013 Clinical Article
125 Preservation of human ovarian follicles within tissue frozen by vitrification in a xeno-free closed system using only ethylene glycol as a permeating cryoprotectant Fertility and Sterility, April 9, 2013 Clinical Article
126 Is there a role for progesterone in the management of acute organophosphate poisoning during pregnancy? Medical Hypotheses, April 9, 2013 Clinical Article
127 A nationwide population-based retrospective cohort study: decreased risk of stroke in cervical cancer patients after receiving treatment Archives of Gynecology and Obstetrics, April 9, 2013 Clinical Article
128 A three-arm randomized phase ii study of oral vinorelbine plus capecitabine versus oral vinorelbine and capecitabine in sequence versus docetaxel plus capecitabine in patients with metastatic breast cancer previously treated with anthracyclines The Breast Journal, April 9, 2013 Clinical Article
129 Progesterone: Indications for the Prevention of Preterm Birth Current Women’s Health Reviews, April 9, 2013 Review Article
130 Trastuzumab emtansine (T-DM1) for HER2-positive breast cancer Current Medical Research and Opinion, April 9, 2013 Clinical Article
131 Epidermal growth factor receptor gene copy number may predict lapatinib sensitivity in HER2-positive metastatic breast cancer Expert Opinion on Pharmacotherapy, April 9, 2013 Clinical Article
132 Association of maternal vitamin D status during pregnancy with bone-mineral content in offspring: a prospective cohort study The Lancet, April 8, 2013 Clinical Article
133 Pregnancy outcomes following gabapentin use: Results of a prospective comparative cohort study Neurology, April 8, 2013 Clinical Article
134 Comparison of sandwich chemo-radiotherapy and six cycles of chemotherapy followed by adjuvant radiotherapy in patients with stage IIIC endometrial cancer: a single center experience Archives of Gynecology and Obstetrics, April 8, 2013 Clinical Article
135 Postoperative administration of dienogest plus estradiol valerate versus levonorgestrel-releasing intrauterine device for prevention of pain relapse and disease recurrence in endometriosis patients Journal of Obstetrics and Gynaecology Research, April 8, 2013 Clinical Article
136 Fertility treatment and childhood cancer risk: A systematic meta-analysis Fertility and Sterility, April 5, 2013 Evidence Based Medicine Review Article
137 Oral contraceptive use and uterine leiomyoma risk: a meta-analysis based on cohort and case-control studies Archives of Gynecology and Obstetrics, April 5, 2013 Evidence Based Medicine Review Article
138 Predictors of neonatal outcomes amongst a methadone- and/or heroin-dependent population referred to a multidisciplinary Perinatal and Family Drug Health Service Australian and New Zealand Journal of Obstetrics and Gynaecology, April 5, 2013 Clinical Article
139 Initiation of ovarian stimulation independent of the menstrual cycle: a case-control study Archives of Gynecology and Obstetrics, April 5, 2013 Clinical Article
140 Teriparatide for Idiopathic Osteoporosis in Premenopausal Women: A Pilot Study Journal of Clinical Endocrinology and Metabolism, April 5, 2013 Clinical Article
Based on a review article published in BMC Infectious Diseases, it has been concluded that antiseptics have equal efficacy to antibiotics in the treatment of bacterial vaginosis. The literature search covered the time period 1966-2010. Benzydamine, chlorhexidine, and polyhexamethylene niguanide were as effective as metronidazole and clindamycin in the short-term treatment of bacterial vaginosis.
Read the article summaryBased on an observational study orchestrated by researchers at the M D Anderson Cancer Center, BRCA2 mutations have been associated with improved survival in patients with high-grade serous ovarian cancer. The 5-year OS in patients with BRCA2 mutations was 61% compared with 25% for patients with BRCA wild-type. The 3-year PFS in patients with BRCA2 mutations was 44% compared with 16% for patients with BRCA wild-type. Patients with BRCA2 mutations exhibited 100% chemosensitivity compared to 82% and 80% for patients with BRCA wild-type and BRCA1 mutations, respectively. Genomic analysis of the tumors from patients with BRCA2 mutations suggested a “mutator phenotype” compared to tumors from patients with BRCA1 mutations.
Read the article summaryIn a study involving 87,025 postmenopausal women, those in the highest quintile of dietary trans fat had an increased risk of ischemic stroke (HR=1.39). In 663,041 person-years of follow-up, 1049 incident cases of ischemic stroke were reported. The effect was attenuated in aspirin users (HR=0.95) compared to non-users (HR=1.66).
Read the article summary1 Prevention of preterm birth by progestational agents: what are the molecular mechanisms? American Journal of Obstetrics and Gynecology, February 25, 2013
2 Relapse of endometrial hyperplasia after conservative treatment: a cohort study with long-term follow-up Human Reproduction, March 14, 2013
3 Preconceptional low-dose aspirin for the prevention of hypertensive pregnancy complications and preterm delivery after IVF: a meta-analysis with individual patient data Human Reproduction, March 28, 2013 Evidence Based Medicine Review Article
4 Recent advances in the management of major obstetric haemorrhage British Journal of Medical Practitioners, April 2, 2013 Free full text
5 Women with pre-existing diabetes under the care of diabetes specialist prior to pregnancy: are their outcomes better? Australian and New Zealand Journal of Obstetrics and Gynaecology, March 6, 2013
6 Labor Induction for Premature Rupture of Membranes Using Vaginal Misoprostol versus Dinoprostone Vaginal Insert American Journal of Perinatology, April 18, 2013
7 Is there a role for progesterone in the management of acute organophosphate poisoning during pregnancy? Medical Hypotheses, April 9, 2013
8 Management of Vulvovaginal Lichen Planus: A New Approach Journal of Lower Genital Tract Disease, March 12, 2013
9 The basic fertility workup in women with polycystic ovary syndrome: a systematic review Fertility and Sterility, April 17, 2013 Evidence Based Medicine Review Article
10 What is in our environment that effects puberty? Reproductive Toxicology, April 22, 2013 Review Article
11 The Use of Aromatase Inhibitors for Ovulation Induction and Superovulation Journal of Clinical Endocrinology and Metabolism, April 17, 2013 Review Article
12 Pregnancy outcomes following gabapentin use: Results of a prospective comparative cohort study Neurology, April 8, 2013
13 Single dose oral ibuprofen plus codeine for acute postoperative pain in adults Cochrane Reviews, April 1, 2013 Review Article
14 A First Look at Chorioamnionitis Management Practice Variation among US Obstetricians Infectious Diseases in Obstetrics and Gynecology, February 11, 2013 Free full text
15 Does 17-alpha-hydroxyprogesterone caproate affect fetal biometry and birth weight? Ultrasound in Obstetrics & Gynecology, April 25, 2013
16 Neonatal Outcomes After Gestational Exposure to Nitrofurantoin Obstetrics and Gynecology, February 21, 2013
17 Methylphenidate use in pregnancy and lactation, a systematic review of evidence. British Journal of Clinical Pharmacology, April 22, 2013
18 Postpartum haemorhage associated with caesarean section and caesarean hysterectomy Best Practice & Research Clinical Obstetrics & Gynaecology, March 11, 2013
19 Methods of term labour induction for women with a previous caesarean section Cochrane Reviews, April 1, 2013 Review Article
20 The Rebirth of Progesterone in the Prevention of Preterm Labor Annals of Pharmacotherapy, March 28, 2013
Indexed Journals in Obstetrics & Gynecology: Obstetrics and Gynecology, American Journal of Obstetrics and Gynecology more
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