Endometrial and ovarian cancer risk increased in PCOS
Based on a meta-analysis reported in Human Reproduction Update, women with polycystic ovarian syndrome [PCOS] (n=919; 11 studies) < 54 years of age, are at increased risk for endometrial (HR = 4.05) and ovarian cancer (HR = 2.52), but not breast cancer (HR = 0.78).
EZH2 predicts poor prognosis in cervical cancer
As reported in the International Journal of Gynecological Pathology, the expression of enhancer zeste homolog (EZH)2 is associated with clinical stage, histologic differentiation, depth of infiltration, and lymph node metastasis in patients with cervical cancer; moreover, EZH2 expression is associated with a decreased OS. Expression of EZH2 was demonstrated in 10% of normal cervical specimens, 52% of LGSIL specimens, 64% of HGSIL specimens, and 68.3% of cervical cancer specimens.
Pre-operative tranexamic acid reduces blood loss in ovarian cancer patients
As reported in ACTA Obstetricia et Gynecologica, a single pre-operative dose of tranexamic acid (15 mg/kg) significantly reduced blood loss (520 cc vs 730 cc) and the transfusion rate (30% vs. 44%) in ovarian cancer patients (n=100) undergoing radical debulking.