Atypical glandular cells associated with increased risk of extrauterine disease
As reported in the International Journal of Gynecologic Cancer, abnormal cervical cytology (atypical glandular cells [AGC] or malignant cells [MC]) on pre-operative cervical cytology predicts extrauterine disease (OR=4.78) and high intermediate risk disease (OR=8.41) in patients with endometrial adenocarcinoma (n=563). In patients with an elevated CA-125 level, the OR for extrauterine and high intermediate risk disease was 13.3 and 5.83, respectively.
Apelin levels correlate with insulin sensitivity and lipid profile in PCOS
As reported in Seizure: European Journal of Epilepsy, patients with epilepsy (n=3182) have a 3-fold increased risk for cerebral stroke. The risk was highest in the 20-39 year age group and those taking high doses of anti-epileptic medications.
EZH2 predicts poor prognosis in cervical cancer
As reported in the International Journal of Gynecological Pathology, the expression of enhancer zeste homolog (EZH)2 is associated with clinical stage, histologic differentiation, depth of infiltration, and lymph node metastasis in patients with cervical cancer; moreover, EZH2 expression is associated with a decreased OS. Expression of EZH2 was demonstrated in 10% of normal cervical specimens, 52% of LGSIL specimens, 64% of HGSIL specimens, and 68.3% of cervical cancer specimens.