Treatment patterns in inpatients with bipolar disorder at a psychiatric university hospital over a 9-year period: focus on mood stabilizers
International Clinical Psychopharmacology,
Walpoth–Niederwanger M et al. – The significant increase in the prescription of MS reflects the increasing awareness and implementation of recent evidence–based medicine guidelines into clinical practice. Clinical decision making, usually made on the basis of individual clinical experience, should always be reevaluated using periodically updated evidence–based medicine guidelines.Methods
- This is a retrospective study of 531 bipolar in patients who were consecutively admitted to the Department for Psychiatry and Psychotherapy in Innsbruck.
- Their complete medical histories were evaluated for psychotropic medications, with a special focus on mood stabilizers (MSs).
- To compare the use of individual MSs or combinations with other psychotropic medications in two preselected observation periods (1999–2003 and 2004–2007), the authors used Fisher’s exact test.
- Overall, the proportion of patients receiving at least one MS increased significantly from 1999–2003 to 2004–2007 (74.1 vs. 83.1%, P=0.011).
- Among the individual MSs, valproate was used most frequently in both time periods, showing a significant increase (P<0.001).
- Prescriptions of quetiapine (P<0.001) and lamotrigine (P=0.033) increased significantly, carbamazepine showed a significant decrease (P<0.001).
- Prescriptions of lithium and olanzapine decreased without reaching significance.