Discovery of phosphatidylcholines and sphingomyelins as biomarkers for ovarian endometriosis
Human Reproduction, 08/08/2012
Vouk K et al. – The results suggest that endometriosis is associated with elevated levels of sphingomyelins and phosphatidylcholines, which might contribute to the suppression of apoptosis and affect lipid–associated signalling pathways. Our findings suggest novel potential routes for therapy by specifically blocking highly up–regulated isoforms of phosphpolipase A2 and lysophosphatidylcholine acyltransferase 4.