Cervical squamous intraepithelial lesions and associated cervical infections in an HIV-positive population in Rural Mpumalanga, South Africa
Swanepoel PJ et al. – This study confirms the high prevalence of progressive human papillomavirus (HPV)–associated cervical disease in a rural Southern African HIV–positive population, which is at least equal to or worse than in other African HIV–positive studies. The high incidence of Bilharzia infection in those cases that underwent cervical cone excision suggests a possible relationship with progressive HPV disease and cervical carcinogenesis. Bacterial vaginosis (perhaps in combination with Bilharzia) may compromise the normal barriers against HPV and HIV infection.