Evaluation of selected ultrasonographic parameters and marker levels in the preoperative differentiation of borderline ovarian tumors and ovarian cancers
Archives of Gynecology and Obstetrics, 07/27/2012
Sobiczewski P et al .–The aim of this study was to perform a comparative assessment of sensitivity and specificity of selected ultrasonographic and clinical parameters for the diagnoses of borderline tumors and ovarian cancers. The proposed model of preoperative evaluation has a sensitivity of 90 % in the differentiation between ovarian cancers and borderline tumors. When combined with intraoperative findings, it allowed optimal surgical therapeutic decisions to be made in patients with borderline ovarian tumors.Methods
- The study retrospectively analyzed 57 patients who underwent surgical treatment in the Maria Sklodowska–Curie Memorial Cancer Center from Jan 01, 2008 to Dec 31, 2009.
- Ovarian cancers were diagnosed in 41 patients, and borderline ovarian tumors in 16 patients.
- Statistical model was developed to determine independent predictive factors that would be useful in preoperative differentiation between both tumors.
- The model included the following factors: menopausal status, tumor morphology, wall thickness (including outgrowths), septal thickness, echogenicity, resistive index, serum CA–125 level, and free fluid in the peritoneal cavity.
- Based on the statistical model developed, independent predictive factors in the differentiation between ovarian cancers and borderline tumors included the menopausal status (P = 0.005), tumor echogenicity (P = 0.047) and the presence of free fluid in the Douglas pouch (P = 0.043).
- With the cutoff value of 13 (with scores below 13 indicating a borderline ovarian tumor, and scores of ?13 indicating ovarian cancer), sensitivity was 90.2 % and specificity was 87 %.