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Associations Between 25-Hydroxyvitamin D and Weight Gain in Elderly Women
Journal of Women's Health, 06/28/2012
Clinical Article
LeBlanc ES et al. – Higher 25(OH)D levels are associated with lower weight gains, suggesting low vitamin D status may predispose to fat accumulation.
Methods- From a community–based multicenter U.S. prospective cohort of 9704 (Study of Osteoporotic Fractures [SOF]), 4659 women aged ≥65 with baseline 25(OH)D measurement were followed for 4.5 years
- They were weighed at baseline and follow–up visits, and a subset (n=1054) had 25(OH)D levels remeasured at follow–up.
- Women with 25(OH)D levels 30 ng/mL had lower baseline weight (141.6 pounds) compared to women with 25(OH)D levels <30 ng/mL (148.6 pounds) (p<0.001).
- Overall, 25(OH)D status was not associated with weight change over 4.5 years, although there was a significant interaction between 25(OH)D status and weight change category (loss, gain, stable) (p<0.0001).
- In women who gained ≥5% weight, those with baseline 25(OH)D levels ≥30 ng/mL gained 16.4 pounds (12.2% of baseline weight) over 4.5 years compared to 18.5 pounds (13.9% of baseline weight) in women with levels <30 ng/mL (p=0.04).
- In women who lost ≥5% weight or remained stable (<5% weight change), there was no association between 25(OH)D status at baseline and weight change.
- Among women who gained weight and had 25(OH)D measured at both visits, having sustained or developing 25(OH)D levels ≥30ng/mL was associated with less weight gain between visits (14.81 vs. 16.34 pounds, p=0.04).
