The effect of body mass index and weight change on epithelial ovarian cancer survival in younger women: a long-term follow-up study
Journal of Women's Health, 06/26/2012
Tyler CP et al. – Although elevated BMI is associated with increased ovarian cancer risk among young women, they found no evidence of its association with ovarian cancer survival in this population.Methods
- They conducted a cohort analysis of 425 women aged 20–54 years with incident epithelial ovarian cancer enrolled during 1980–1982 in Cancer and Steroid Hormone (CASH), a population–based, case–control study. Participants' vital status was ascertained though linkage with the Surveillance, Epidemiology and End Results (SEER) program.
- Using Cox proportional hazards models, they estimated adjusted hazard ratios (HR) and 95% confidence intervals (CI) for the association between survival and usual adult BMI, BMI at age 18, and weight change from age 18 to adult.
- During a follow–up of up to 17 years, 215 women died.
- Compared to women with an adult BMI in the lowest quartile (<20.7), women in the second (20.8–22.5), third (22.6–24.9), and fourth (≥25.0) quartiles were not at increased risk for death (HR 1.2, 95% CI 0.8–1.8; HR 1.1, 95% CI 0.7–1.6; and HR 0.9, 95% CI 0.6–1.4, respectively) (p trend=0.6).
- Similarly, neither age 18 BMI nor weight change were associated with ovarian cancer survival.