Placental size at 19 weeks predicts offspring bone mass at birth: Findings from the Southampton Women's Survey
Placenta,

Holroyd CR et al. – Authors found that placental volume at 19 weeks gestation was positively associated with neonatal bone size and mineral content. These relationships appeared independent of those maternal factors known to be associated with neonatal bone mass, consistent with notion that such maternal influences might act through modulation of aspects of placental function, e.g. utero–placental blood flow or maternal nutrient concentrations, rather than placental size itself. Low placental volume early in pregnancy may be a marker of a reduced postnatal skeletal size and increased risk of later fracture.

Methods
  • 914 mother–neonate pairs were included. Placental dimensions were measured via ultrasound at 19 weeks gestation.
  • X–ray absorptiometry (DXA) was performed on the neonates within the first two weeks of life.

Results
  • Authors observed positive relationships between placental volume at 19 weeks, and neonatal bone area (BA; r = 0.26, p < 0.001), bone mineral content (BMC; r = 0.25, p < 0.001) and bone mineral density (BMD; r = 0.10, p = 0.001).
  • Thus placental volume accounted for 6.25% and 1.2% of the variation in neonatal BMC and BMD respectively at birth.
  • These associations remained after adjustment for maternal factors previously shown to be associated with neonatal bone mineral accrual (maternal height, smoking, walking speed in late pregnancy, serum 25(OH) vitamin D and triceps skinfold thickness).

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Obstetrics & Gynecology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Obstetrics & Gynecology Articles

1 Vitamin D and pregnancy outcomes Current Opinion in Obstetrics and Gynecology, November 14, 2014    Review Article

2 Diabetic pregnancy: An overview of current guidelines and clinical practice Current Opinion in Obstetrics and Gynecology, November 21, 2014    Review Article

3 Risk of stroke in healthy postmenopausal women during and after hormone therapy: A meta-analysis Menopause, November 11, 2014    Clinical Article

4 Effects of sea buckthorn oil intake on vaginal atrophy in postmenopausal women: A randomized, double-blind, placebo-controlled study Maturitas, November 4, 2014    Clinical Article

5 Vitamin D status in early pregnancy and risk of preeclampsia (E14-0363) American Journal of Obstetrics and Gynecology, November 26, 2014    Clinical Article

6 Effect of ginger (Zingiber officinale) on heavy menstrual bleeding: a placebo-controlled, randomized clinical trial Phytotherapy Research, October 13, 2014    Clinical Article

7 Incidence of hypercalciuria and hypercalcemia during vitamin D and calcium supplementation in older women Menopause, November 7, 2014    Clinical Article

8 Pathologic findings at risk-reducing salpingo-oophorectomy: Primary Results From Gynecologic Oncology Group Trial GOG-0199 Journal of Clinical Oncology, September 19, 2014    Clinical Article

9 Maternal consumption of coffee and tea during pregnancy and risk of childhood brain tumors: Results from an Australian case-control study Cancer Causes and Control, October 31, 2014    Clinical Article

10 Use of antidepressants and association with elective termination of pregnancy: Population based case-control study BJOG: An International Journal of Obstetrics and Gynaecology, November 24, 2014    Clinical Article

11 Anti-mullerian hormone as a diagnostic and prognostic tool for PCOS patients Journal of Assisted Reproduction and Genetics, August 22, 2014    Clinical Article

12 Favorable effects of vitamin D supplementation on pregnancy outcomes in gestational diabetes: A double blind randomized controlled clinical trial Hormone and Metabolic Research, November 13, 2014    Clinical Article

13 Common cholesterol-fighting drug may prevent hysterectomies in women with uterine fibroids University of Texas Medical Branch at Galveston, November 14, 2014

14 Nutrition advice during pregnancy: Do women receive it and can health professionals provide it? Maternal and Child Health Journal , November 18, 2014    Clinical Article

15 Dietary energy density is positively associated with breast density among young women Journal of the Academy of Nutrition and Dietetics, November 12, 2014    Clinical Article

16 Effects of vitamin E on bone remodeling in perimenopausal women: Mini review Maturitas, November 6, 2014    Review Article

17 Healthy lifestyle and risk of breast cancer among postmenopausal women in the European Prospective Investigation into Cancer and Nutrition cohort study International Journal of Cancer, November 17, 2014    Clinical Article

18 Diagnosis and treatment of polycystic ovary syndrome: an endocrine society clinical practice guideline Full Text Journal of Clinical Endocrinology and Metabolism, November 5, 2013    Free full text    Clinical Guideline

19 Serum vitamin D levels are inversely related with nonalcoholic fatty liver disease independent of visceral obesity in Chinese postmenopausal women Clinical and Experimental Pharmacology and Physiology, November 3, 2014    Clinical Article

20 What differentiates symptomatic from asymptomatic women with lichen sclerosus Gynecologic and Obstetric Investigation, October 30, 2014    Clinical Article

Indexed Journals in Obstetrics & Gynecology: Obstetrics and Gynecology, American Journal of Obstetrics and Gynecologymore