Subtle progesterone rise on the day of human chorionic gonadotropin administration is associated with lower live birth rates in women undergoing assisted reproductive technology: a retrospective study with 2,555 fresh embryo transfers
Fertility and Sterility, 05/31/2012
Ochsenkuhn R et al. – A rise of serum P levels ≥2.0 ng/mL on the day of hCG administration is associated with impaired early embryo implantation and reduced live birth rate in cycles with GnRH agonists after day–5 fresh ET.Methods
- A total of 2,555 women undergoing fresh ET on day 5 in 2,062 GnRH agonist and 493 GnRH antagonist cycles.
- Live birth rate in cycles with GnRH agonists was significantly lower in women with P levels ≥2.0 ng/mL (17.4%) on the day of hCG administration as compared with women with P levels <1.5 ng/mL (24.6%) and 1.5–1.99 ng/mL (26.7%).
- No such significant differences in live birth rates in cycles with GnRH antagonist could be observed.