Prepregnancy cardiometabolic and inflammatory risk factors and subsequent risk of hypertensive disorders of pregnancy
American Journal of Obstetrics and Gynecology, 05/25/2012
Hedderson MM et al. – Prepregnancy cardiometabolic and inflammation risk profile may help clinicians identify high risk women to target for early intervention or management of hypertensive disorder of pregnancy.Methods
- A retrospective cohort study of 3,380 women who took part in a comprehensive multiphasic health checkup (MHC) exam between 1984 and 1996 and had a subsequent delivery in Kaiser Permanente Northern California.
- 205 women were diagnosed with a hypertensive disorder of pregnancy.
- Prepregnancy measurements of overweight/obesity (BMI ≥ 25.0 kg/m2), pre–hypertension and inflammation (leukocytes ≥ 7.2 103/μL) were independently associated with hypertensive disorder of pregnancy risk [odds ratios (95% confidence intervals): 1.6 (1.2–2.3), 2.1(1.5–2.8) and 1.6 (1.1–2.3), respectively].
- Being overweight/obese and having pre–hypertension before pregnancy was associated with a 3.5–fold increased risk of hypertensive disorder of pregnancy compared with women with normal levels of both risk factors.