Intravenous ketamine compared with diclofenac suppository in suppressing acute postoperative pain in women undergoing gynecologic laparoscopy
Journal of Anesthesia, 05/14/2012Vosoughin M et al.
Diclofenac 100–mg suppositories were more effective in suppressing acute pain than 0.15mg/kg intravenous ketamine in women undergoing elective gynecologic laparoscopy, with fewer untoward complications.
In a double–blind, randomized clinical trial, 80 patients were selected and entered the study.
After the induction of general anesthesia, one group received 0.15mg/kg intravenous ketamine and the other group received a 100–mg rectal diclofenac suppository.
The two groups were compared regarding acute pain scores, postoperative morphine requirements, and untoward complications.
Pain scores and morphine requirements were lower in the rectal diclofenac suppository group at the 1st, 3rd, and 6th postoperative hours.
Higher incidences of postoperative nausea and vomiting (PONV), delusions, and oral secretions were observed in the ketamine group.
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