Relative imbalances in the expression of catechol-O-methyltransferase and cytochrome P450 in breast cancer tissue and their association with breast carcinoma
Maturitas,

Zhao YN et al. – Significantly deceased expression of estradiol–metabolizing enzymes might result in the excess exposure of intratumoural E2, which could be one of the important risk factors for breast cancer. Significantly elevated COMT expression suggested that COMT could play a key role in breast tumor formation.

Methods
  • The mRNA expression levels of cytochrome P450 (CYP) 1A1, 1B1 and 3A4 and catechol–O–methyltransferase (COMT) were examined in the breast tumor tissues, matched adjacent non–tumor tissues and the tissues with benign breast disease (BBD) by fluorescent quantitative real–time PCR.

Results
  • Compared to BBD tissue, the mRNA expression of CYP1A1, CYP1B1 and CYP3A4 significantly reduced by 81.8%, 77.5%, and 85.6%, respectively, in the breast tumor tissue and by 27.2%, 38.8%, and 51.3%, respectively, in the adjacent non–tumor tissue in average (p<0.0001).
  • COMT mRNA was 6.9 and 6.4 fold higher in the breast tumor and match non–tumor tissue (p<0.0001) than in the BBD, respectively.
  • The level of COMT detected in pre–menopausal group and lymph nodal stage N1–N2 group was lower than that in post–menopausal group (p=0.0292) and N0 group (p=0.0389), respectively.

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Obstetrics & Gynecology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Obstetrics & Gynecology Articles

1 Vitamin D and pregnancy outcomes Current Opinion in Obstetrics and Gynecology, November 14, 2014    Review Article

2 Diabetic pregnancy: An overview of current guidelines and clinical practice Current Opinion in Obstetrics and Gynecology, November 21, 2014    Review Article

3 Risk of stroke in healthy postmenopausal women during and after hormone therapy: A meta-analysis Menopause, November 11, 2014    Clinical Article

4 Effects of sea buckthorn oil intake on vaginal atrophy in postmenopausal women: A randomized, double-blind, placebo-controlled study Maturitas, November 4, 2014    Clinical Article

5 Vitamin D status in early pregnancy and risk of preeclampsia (E14-0363) American Journal of Obstetrics and Gynecology, November 26, 2014    Clinical Article

6 Effect of ginger (Zingiber officinale) on heavy menstrual bleeding: a placebo-controlled, randomized clinical trial Phytotherapy Research, October 13, 2014    Clinical Article

7 Incidence of hypercalciuria and hypercalcemia during vitamin D and calcium supplementation in older women Menopause, November 7, 2014    Clinical Article

8 Pathologic findings at risk-reducing salpingo-oophorectomy: Primary Results From Gynecologic Oncology Group Trial GOG-0199 Journal of Clinical Oncology, September 19, 2014    Clinical Article

9 Maternal consumption of coffee and tea during pregnancy and risk of childhood brain tumors: Results from an Australian case-control study Cancer Causes and Control, October 31, 2014    Clinical Article

10 Use of antidepressants and association with elective termination of pregnancy: Population based case-control study BJOG: An International Journal of Obstetrics and Gynaecology, November 24, 2014    Clinical Article

11 Anti-mullerian hormone as a diagnostic and prognostic tool for PCOS patients Journal of Assisted Reproduction and Genetics, August 22, 2014    Clinical Article

12 Favorable effects of vitamin D supplementation on pregnancy outcomes in gestational diabetes: A double blind randomized controlled clinical trial Hormone and Metabolic Research, November 13, 2014    Clinical Article

13 Common cholesterol-fighting drug may prevent hysterectomies in women with uterine fibroids University of Texas Medical Branch at Galveston, November 14, 2014

14 Nutrition advice during pregnancy: Do women receive it and can health professionals provide it? Maternal and Child Health Journal , November 18, 2014    Clinical Article

15 Dietary energy density is positively associated with breast density among young women Journal of the Academy of Nutrition and Dietetics, November 12, 2014    Clinical Article

16 Effects of vitamin E on bone remodeling in perimenopausal women: Mini review Maturitas, November 6, 2014    Review Article

17 Healthy lifestyle and risk of breast cancer among postmenopausal women in the European Prospective Investigation into Cancer and Nutrition cohort study International Journal of Cancer, November 17, 2014    Clinical Article

18 Diagnosis and treatment of polycystic ovary syndrome: an endocrine society clinical practice guideline Full Text Journal of Clinical Endocrinology and Metabolism, November 5, 2013    Free full text    Clinical Guideline

19 Serum vitamin D levels are inversely related with nonalcoholic fatty liver disease independent of visceral obesity in Chinese postmenopausal women Clinical and Experimental Pharmacology and Physiology, November 3, 2014    Clinical Article

20 What differentiates symptomatic from asymptomatic women with lichen sclerosus Gynecologic and Obstetric Investigation, October 30, 2014    Clinical Article

Indexed Journals in Obstetrics & Gynecology: Obstetrics and Gynecology, American Journal of Obstetrics and Gynecologymore