Maternal BMI, glucose tolerance, and adverse pregnancy outcomes
American Journal of Obstetrics and Gynecology, 05/07/2012
Stuebe AM et al. – Among women with untreated mild gestational glucose intolerance, pregravid body mass index (BMI) is associated with increased gestational hypertension, birth weight and neonatal fat mass, independent of oral glucose tolerance test (OGTT) values.Methods
- In this secondary analysis of a cohort of women with untreated mild gestational glucose intolerance, defined as 50g glucose loading test between 135 and 199 mg/dL and fasting glucose <95 mg/dL, authors modeled the association between pregravid BMI, OGTT results, and both pregnancy complications and neonatal adiposity.
- Among 1250 participants, both pregravid BMI and glucose at hour 3 of the OGTT were associated with increased risk of gestational hypertension.
- Maternal pregravid BMI was also positively associated with LGA, and both maternal BMI and fasting glucose were associated with birth–weight z–score and neonatal fat mass.