Harris HR et al. – The authors observed no significant association between folate and ovarian cancer risk. One–carbon metabolism related nutrients, especially vitamin B6 and methionine, may lower ovarian cancer risk.Methods
- The authors investigated the association between folate, methionine, vitamin B6, vitamin B12 and alcohol among 1910 women with ovarian cancer and 1989 controls from a case-control study conducted in eastern Massachusetts and New Hampshire from 1992 to 2008.
- Diet was assessed via food frequency questionnaire.
- Participants were asked to recall diet one-year before diagnosis or interview.
- Logistic regression models were used to calculate odds ratios (OR) and 95% confidence intervals (95% CIs).
- They also examined whether the associations varied by ovarian cancer histologies using polytomous logistic regression.
- The authors observed an inverse association between dietary vitamin B6 (covariate-adjusted OR=0.76, 95% CI 0.64-0.92; ptrend=0.002) and methionine intake (covariate-adjusted OR=0.72, 95% CI=0.60-0.87; ptrend<0.001) and ovarian cancer risk comparing the highest to lowest quartile.
- The association with dietary vitamin B6 was strongest for serous borderline (covariate-adjusted OR=0.49, 95% CI=0.32-0.77; ptrend=0.001) and serous invasive (covariate-adjusted OR=0.74, 95% CI=0.58-0.94; ptrend=0.012) subtypes.