Circulating vitamin D correlates with serum antimüllerian hormone levels in late-reproductive-aged women: Women's Interagency HIV Study
Fertility and Sterility, 04/12/2012
Merhi ZO et al. – A novel relationship is reported between circulating 25OH–D and AMH in women aged ≥40 years, suggesting that 25OH–D deficiency might be associated with lower ovarian reserve in late–reproductive–aged women.Methods
- All premenopausal women (n = 388) with regular menstrual cycles were included and subdivided into three groups: group 1 with age <35 years (n = 128), group 2 with age 35–39 years (n = 119), and group 3 with age ≥40 years (n = 141).
- Serum for 25OH–D, AMH, fasting glucose and insulin, and creatinine levels.
- Correlation between 25OH–D and AMH before and after adjusting for HIV status, body mass index, race, smoking, illicit drug use, glucose and insulin levels, estimated glomerular filtration rate, and geographic site of participation.
- After adjusting for all covariates, the regression slope in all participants for total 25OH–D predicting log10AMH for 25–year–olds (youngest participant) was -0.001 (SE = 0.008); and for 45–year–olds (oldest participant) the corresponding slope was +0.011 (SE = 0.005).
- Fasting insulin level was negatively correlated with serum AMH.
- The regression slope for the correlation between 25OH–D and AMH in group 1 was +0.002 (SE = 0.006); in group 2 was +0.006 (SE = 0.005); and in group 3 was +0.011 (SE = 0.005).
- There was no association between HIV and AMH.