Concurrent Chemoradiotherapy with Paclitaxel and Cisplatin for Adenocarcinoma of the Cervix

Anticancer Research, 04/09/2012

Nagai Y et al. – The present study demonstrated that cisplatin–based concurrent chemoradiotherapy (CCRT)–TP achieved much better local control for adenocarcinoma of the cervix, leading to a decrease in locoregional recurrence.

Methods

  • The authors retrospectively analyzed data for 32 patients with stage IIB–IVA cervical adenocarcinoma who were treated with radiotherapy (RT) or CCRT.
  • Fourteen patients were treated with RT, 8 with CCRT using cisplatin alone (CCRT-P), and 10 with CCRT using cisplatin plus paclitaxel (CCRT-TP).

Results

  • Complete response was achieved in 7/14 patients in the RT group, 4/8 patients in the CCRT-P group, and 9/10 patients in the CCRT-TP group.
  • Ten out of the 14 patients in the RT, 7/8 patients in the CCRT-P, and 2/10 patients in the CCRT-TP groups experienced locoregional recurrence.
  • The 5-year overall survival rate in the RT, CCRT-P, and CCRT-TP groups was 7.1%, 25.0%, and 74.1%, respectively (p=0.0094).

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