Chemerin inhibits IGF-1-induced progesterone and estradiol secretion in human granulosa cells
Human Reproduction, 04/13/2012
Reverchon M et al. – Taken together, chemerin and its receptor (CMKLR1) are present and active in hGCs. Chemerin reduces IGF–1–induced steroidogenesis and cell proliferation through a decrease in the activation of IGF–1R signalling pathways in primary hGCs.