Chemerin inhibits IGF-1-induced progesterone and estradiol secretion in human granulosa cells

Human Reproduction, 04/13/2012

Taken together, chemerin and its receptor (CMKLR1) are present and active in hGCs. Chemerin reduces IGF–1–induced steroidogenesis and cell proliferation through a decrease in the activation of IGF–1R signalling pathways in primary hGCs.

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