Maternal caffeine consumption and sine causa recurrent miscarriage
European Journal of Obstetrics & Gynecology and Reproductive Biology, 10/12/2011
Stefanidou EM et al. – Caffeine intake may increase the risk of sine causa recurrent miscarriage regardless of pregnancy–related symptoms and relevant covariates (such as age and tobacco use).Methods
- A retrospective case–control study was conducted in the Department of Obstetrics and Gynecology, University of Turin between 2008 and 2009.
- Fifty-two sine causa recurrent miscarriers and 260 healthy pregnant women were assessed.
- Data were analyzed using SPSS 17 for Windows.
- Caffeine consumption during the periconceptional period and early gestation was higher in sine causa recurrent miscarriers compared to healthy pregnant women.
- Moreover, each caffeine intake of 100mg/day was associated with an increased odds ratio for sine causa recurrent miscarriage of 2724 (p for trend 0.001; 95% confidence interval [CI], 2.715–2.733), after adjusting for relevant confounding covariates.