Antimullerian hormone and polycystic ovary syndrome
Fertility and Sterility, 05/11/2011
Lin YH et al. – Elevated serum antimullerian hormone (AMH) levels increase the risk of polycystic ovary syndrome (PCOS) but do not affect the risk of insulin resistance or metabolic syndrome.Methods
- Prospective study
- 290 women were included in the study.
- The main outcome measures were parameters related to insulin resistance and metabolic syndrome.
- Women with polycystic ovary morphology had significantly higher AMH levels than women in the control group.
- The prevalence of PCOS increased from 21% in the low-AMH (<4 ng/mL) group to 37% in the moderate-AMH (4–11 ng/mL) group and 80% in the high-AMH (>11 ng/mL) group.
- Significant differences in insulin resistance parameters were not observed among groups.
- The results of the correlation analysis revealed that AMH levels were positively correlated with LH, total T, A, and total cholesterol content.
- AMH levels were negatively correlated with age, body mass index, and the number of menstrual cycles per year.
- AMH levels were not correlated with insulin resistance parameters.