Screening for fetal spina bifida by ultrasound examination in the first trimester of pregnancy using fetal biparietal diameter
American Journal of Obstetrics and Gynecology, 05/25/2012Bernard JP et al.
Simple and reproducible BPD at 11–14 weeks of gestation could detect half the cases of open fetal spina bifida by identifying 5% of pregnancies for expert scanning in first and second trimester examinations of the fetal spine and cranium.
34,951 unselected consecutive pregnancies included 18 with spina bifida.
Another 28 cases were referred for assessment.
Biometric measurements were expressed in multiples of the median for crown–rump length.
Biparietal diameter (BPD) was smaller in spina bifida (P<0.0001).
22/44 (50%) cases with spina bifida aperta had a BPD < 5th centile.
BPD was independent of maternal adiposity and smoking status.
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