Intraabdominal adhesion formation is associated with differential mRNA expression of metabolic genes PDHb and SDHa
Archives of Gynecology and Obstetrics, 05/14/2012Wallwiener M et al.
The increased expression level of HIF–1α in the peritoneal tissue of ischemic buttons associated with postsurgical adhesions supports the major role for hypoxia in influencing peritoneal expression patterns of genes involved in the process of adhesion formation. As pivotal metabolic genes are upregulated, this seems to be an anabolic process associated with increased cellular metabolism.
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