Antenatal corticosteroids for fetal lung maturation in threatened preterm delivery: indications and administration
Archives of Gynecology and Obstetrics, 05/03/2012Surbek D et al.
The evidence to date is clearly against the routine administration of multiple antenatal steroid courses. In special clinical situations, a second course of betamethasone (“rescue course”) may be justifiable. Tocolysis during administration of steroids is not routinely indicated in the absence of contractions, cervical shortening or rupture of membranes.
The published literature (PubMed search), as well as the recommendations of other national societies, has been searched and taken into consideration for these recommendations.
The standard regimen of antenatal corticosteroids involves a single course of 2 × 12 mg betamethasone administered intramuscularly within 24 h.
The administration of corticosteroids usually is performed between 24 and 34 weeks gestation.
However, under particular circumstances it may be beneficial even at 23 weeks and at 35–36 weeks of gestation.
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