Early Administration of Low-Dose Aspirin for the Prevention of Preterm and Term Preeclampsia: A Systematic Review and Meta-Analysis

Fetal Diagnosis and Therapy, 04/26/2012

Low–dose aspirin administrated at or before 16 weeks of gestation reduces the risk of preterm but not term preeclampsia.

Methods

  • A systematic review and meta–analysis of randomized controlled trials were performed.
  • Women who were randomized to low–dose aspirin or placebo/no treatment at or before 16 weeks of gestation were included.
  • The outcomes of interest were preterm preeclampsia (delivery <37 weeks) and term preeclampsia.
  • Pooled relative risks (RR) with their 95% confidence intervals (CI) were computed.

Results

  • The search identified 7,941 citations but only five trials on a combined total of 556 women fulfilled the inclusion criteria.
  • When compared to controls, aspirin initiated ≤16 weeks of gestation was associated with a major reduction of the risk of preterm preeclampsia (RR 0.11, 95% CI 0.04–0.33) but had no significant effect on term preeclampsia (RR 0.98, 95% CI 0.42–2.33).

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