Use of erlotinib throughout pregnancy: A case-report of a patient with metastatic lung adenocarcinoma

Lung Cancer, 04/26/2012

The authors present the case of a 40year–old female patient with stage IV lung adenocarcinoma, mediastinal, bone and cerebral metastasis, a EGFR mutation and no smoking history, who had begun first line treatment with erlotinib 150mg once daily. After two and a half months of treatment a fourteen–week pregnancy was documented, and after informing on fetal risks secondary to erlotinib use and maternal risks secondary to treatment withholding, she decided to continue with treatment under clinical surveillance by both the oncology and obstetrics clinics. Imaging assessment after eight months of treatment showed complete bone and central nervous system response and partial lung and mediastinal response. The patient is currently undergoing the 11th month of treatment and is asymptomatic, the baby is 4months old and is in good health.

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