Coffee consumption and risk of endometrial cancer: Findings from a large up-to-date meta-analysis

International Journal of Cancer, 04/24/2012

Je Y et al. – The findings suggest that increased coffee intake is associated with a reduced risk of endometrial cancer, consistently observed for cohort and case–control studies.


  • The authors conducted a meta-analysis of observational studies published up to October 2011 through a search of MEDLINE and EMBASE databases and the reference lists of retrieved article.
  • Pooled relative risks (RRs) with 95% confidence intervals (CIs) were calculated using a random-effects model, and generalized least square trend estimation was used to assess dose–response relationships.
  • A total of 16 studies (10 case-control and six cohort studies) on coffee intake with 6,628 endometrial cancer cases were included in the meta-analysis.


  • The pooled RR of endometrial cancer for the highest versus lowest categories of coffee intake was 0.71 (95% CI: 0.62-0.81; p for heterogeneity=0.13).
  • By study design, the pooled RRs were 0.69 (95% CI: 0.55-0.87) for case–control studies and 0.70 (95% CI: 0.61-0.80) for cohort studies.
  • By geographic region, the inverse association was stronger for three Japanese studies (pooled RR=0.40; 95% CI: 0.25-0.63) than five studies from USA/Canada (pooled RR=0.69; 95% CI: 0.60-0.79) or eight studies from Europe (pooled RR=0.79; 95% CI: 0.63-0.99).
  • An increment of one cup per day of coffee intake conferred a pooled RR of 0.92 (95% CI: 0.90-0.95).

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