Folate, vitamin B6, vitamin B12, methionine and alcohol intake in relation to ovarian cancer risk

International Journal of Cancer, 04/20/2012

Harris HR et al. – The authors observed no significant association between folate and ovarian cancer risk. One–carbon metabolism related nutrients, especially vitamin B6 and methionine, may lower ovarian cancer risk.


  • The authors investigated the association between folate, methionine, vitamin B6, vitamin B12 and alcohol among 1910 women with ovarian cancer and 1989 controls from a case-control study conducted in eastern Massachusetts and New Hampshire from 1992 to 2008.
  • Diet was assessed via food frequency questionnaire.
  • Participants were asked to recall diet one-year before diagnosis or interview.
  • Logistic regression models were used to calculate odds ratios (OR) and 95% confidence intervals (95% CIs).
  • They also examined whether the associations varied by ovarian cancer histologies using polytomous logistic regression.


  • The authors observed an inverse association between dietary vitamin B6 (covariate-adjusted OR=0.76, 95% CI 0.64-0.92; ptrend=0.002) and methionine intake (covariate-adjusted OR=0.72, 95% CI=0.60-0.87; ptrend<0.001) and ovarian cancer risk comparing the highest to lowest quartile.
  • The association with dietary vitamin B6 was strongest for serous borderline (covariate-adjusted OR=0.49, 95% CI=0.32-0.77; ptrend=0.001) and serous invasive (covariate-adjusted OR=0.74, 95% CI=0.58-0.94; ptrend=0.012) subtypes.

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