Folate, vitamin B6, vitamin B12, methionine and alcohol intake in relation to ovarian cancer risk
International Journal of Cancer, 04/20/2012
Harris HR et al. – The authors observed no significant association between folate and ovarian cancer risk. One–carbon metabolism related nutrients, especially vitamin B6 and methionine, may lower ovarian cancer risk.
The authors investigated the association between folate, methionine, vitamin B6, vitamin B12 and alcohol among 1910 women with ovarian cancer and 1989 controls from a case-control study conducted in eastern Massachusetts and New Hampshire from 1992 to 2008.
Diet was assessed via food frequency questionnaire.
Participants were asked to recall diet one-year before diagnosis or interview.
Logistic regression models were used to calculate odds ratios (OR) and 95% confidence intervals (95% CIs).
They also examined whether the associations varied by ovarian cancer histologies using polytomous logistic regression.
The authors observed an inverse association between dietary vitamin B6 (covariate-adjusted OR=0.76, 95% CI 0.64-0.92; ptrend=0.002) and methionine intake (covariate-adjusted OR=0.72, 95% CI=0.60-0.87; ptrend<0.001) and ovarian cancer risk comparing the highest to lowest quartile.
The association with dietary vitamin B6 was strongest for serous borderline (covariate-adjusted OR=0.49, 95% CI=0.32-0.77; ptrend=0.001) and serous invasive (covariate-adjusted OR=0.74, 95% CI=0.58-0.94; ptrend=0.012) subtypes.
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