First trimester placental volume and three dimensional power doppler ultrasonography in type I diabetic pregnancies

Prenatal Diagnosis, 04/19/2012

In type I diabetic mothers, placental vascular indices are increased and these modifications are more evident in pregnancies with poor first trimester glycemic control.


  • 3D–power Doppler ultrasonography of the placenta was performed at 11+0–13+6 weeks in 32 pregnancies complicated by type I diabetes.
  • Placental volume, vascularization index (VI), flow index (FI), and vascularization flow index (VFI) were calculated using a standardized setting.


  • In nine pregnancies, a poor first trimester glycemic control was present as expressed by HbA1c levels≥≥7%, whereas in the remaining 23 mothers, the HbA1c concentrations were <7%.
  • No differences were found in the placental volumes of diabetic mothers when compared with reference limits. 3D Doppler placental vascular indices were significantly higher in diabetic mothers (VI delta value 0.99, p=0.0012; FI delta value 0.64, p=0.0008; VFI delta value 1.28, p=0.0039) when compared with reference limits.
  • Pregnancies with HbA1c ≥7% exhibited higher placental vascular indices when compared with diabetic mothers with better glycemic control.

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