Escitalopram treatment of menopausal hot flashes

Menopause, 10/05/2011

Freedman RR et al. – Escitalopram at 10 or 20 mg/day is not effective in the treatment of menopausal hot flashes.


  • Two studies were performed: 16 women received 10 mg/day and 26 women received 20 mg/day escitalopram for 8 weeks.
  • They were randomly assigned in equal numbers to receive active drug or placebo in a double-blind fashion.
  • Hot flash frequency was measured with an ambulatory recorder during the first 3 weeks and during the 8th week of the study.
  • Rectal temperature threshold for sweating was measured during the 1st and 8th weeks of the study using published methods.


  • In the first study, there were no significant effects whatsoever for any measure.
  • In the second study, the escitalopram group showed an average decline in hot flash frequency of 14.4%, whereas the placebo group showed an average increase of 6.7% (P < 0.05).
  • However, there were no significant effects across time for either group.
  • There were no significant effects whatsoever for rectal temperature sweating thresholds.

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