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Mortality, leukemic risk, and cardiovascular toxicity of adjuvant anthracycline and taxane chemotherapy in breast cancer: a meta-analysis

Petrelli F et al. – This meta–analysis suggests that anthracycline (A)+taxanes (T)–based adjuvant chemotherapy is as toxic as A alone with no significant difference in non–breast cancer–related mortality. However, sequential A+T schedules are associated with less toxicity, but a significant increase in non–breast cancer–related mortality compared with control arms with a greater dose of A. [more...]

Breast Cancer Research and Treatment

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