Obstetrics & Gynecology News & Articles

1 Immunogenicity of 2 Doses of HPV Vaccine in Younger Adolescents vs 3 Doses in Young Women A Randomized Clinical Trial Immunogenicity of HPV Vaccine in Girls vs Women JAMA, May 6, 2013
Dobson SRM et al. - Global use of human papillomavirus (hpv) vaccines to prevent cervical cancer is impeded by cost. A 2-dose schedule for girls may be possible. To determine whether mean antibody levels to hpv-16 and hpv-18 among girls receiving 2 doses was noninferior to women receiving 3 doses. Among girls who received 2 doses of hpv vaccine 6 months apart, responses to hpv-16 and hpv-18 one month after the last dose were noninferior to those among young ...

2 Association of Chlamydia trachomatis Infection and Herpes Simplex Virus Type 2 Serostatus With Genital Human Papillomavirus Infection in Men: The HPV in Men Study Sexually Transmitted Diseases, March 15, 2013
Alberts C. J.et al. - This study assesses whether Chlamydia trachomatis (CT) infection and herpes simplex virus type 2 (HSV-2) serostatus are associated with genital hpv prevalence, an early event in hpv-related pathogenesis.It was concluded that in this population, CT infection and HSV-2 serostatus were associated with prevalent genital hpv infection. Future prospective studies should investigate whether these infections influence hpv acquisition and/or persistence. ...

3 Human papillomavirus infection and colorectal cancer risk: a meta-analysis Colorectal Disease, May 3, 2013
Damin DC et al. - Human papillomavirus (hpv) infection is associated with cervical cancer, but whether it is involved in colorectal carcinogenesis is controversial. The authors conducted a meta-analysis to evaluate the association between hpv and colorectal adenocarcinoma. The results provide quantitative evidence for an association between hpv infection and colorectal cancer risk. Methods A search of the MEDLINE database was performed using the MESH terms “hpv”, “human ...

4 Population-based evaluation of type-specific HPV prevalence among women in British Columbia, Canada Vaccine , February 13, 2013
Ogilvie GS et al. - British Columbia (BC) introduced a school-based hpv vaccine program in September 2008. As part of the hpv vaccine program evaluation, the authors determined the type-specific hpv prevalence in a population-based sample of women presenting for routine cervical cancer screening in the province. Comparable to other evaluations, hrhpv positivity was highest among younger women and hpv 16 was the most frequent genotype detected. These baseline estimates ...

5 Factors influencing the willingness of US women to vaccinate their daughters against the human papillomavirus to prevent cervical cancer Medical Oncology, April 30, 2013
Lai JY et al. - Among US women, hpv knowledge level was high, but it was not associated with the willingness to vaccinate their daughters against hpv. Interventions focused on alleviating racial disparities might better modify the use of the hpv vaccine. Methods Our aims were to evaluate the willingness of US women to use the hpv vaccine in their daughters, examine their current understanding of hpv, and determine the impact of hpv knowledge and other socio-demographic factors on ...

6 Effectiveness of Decision Support for Families, Clinicians, or Both on HPV Vaccine Receipt Pediatrics, May 10, 2013
Fiks AG et al. – To improve human papillomavirus (hpv) vaccination rates, they studied the effectiveness of targeting automated decision support to families, clinicians, or both. A clinician–focused intervention was most effective for initiating the hpv vaccination series, whereas a family–focused intervention promoted completion. Decision support directed at both clinicians and families most effectively promotes hpv vaccine series receipt. Methods Twenty-two primary care practices were ...

7 HPV associated with recurrent respiratory papillomatosis Future Virology, May 7, 2013
Seedat RY et al. - Papillomaviruses are members of the Papillomaviridae family. Over 150 hpv types have been identified. Recurrent respiratory papillomatosis (RRP) is a chronic condition caused by hpv characterized by recurrent papillomas of the respiratory tract, mainly the larynx. During the early stages, the condition presents with hoarseness, while more advanced disease presents with stridor and respiratory distress. There is no specific cure and treatment consists of repeated ...

8 Knowledge and awareness of HPV and the HPV vaccine among young women in the first routinely vaccinated cohort in England Vaccine , February 12, 2013
Bowyer HL et al. - A national school-based human papillomavirus (hpv) vaccination programme has been available for 12–13 year old females in the UK since 2008, offering protection against hpv types 16 and 18, which are responsible for the majority of cervical cancer. Little is known about hpv knowledge in girls who have been offered the vaccine. Girls offered the school-based vaccine in the first routine cohort (n = 1033) were recruited from 13 schools in London three years ...

9 Modeling the impact of quadrivalent HPV vaccination on the incidence of Pap test abnormalities in the United States Vaccine , May 14, 2013
Chesson HW et al. - The authors present data on Pap test results and hpv prevalence from the hpv Sentinel Surveillance project, a multiyear surveillance project enrolling women from a diverse set of 26 clinics throughout the US from 2003 to 2005. The authors use mathematical modeling to illustrate the potential timing and magnitude of decreases in Pap test abnormalities in sexually transmitted disease (STD), family planning, and primary care clinics in the US as a result of hpv ...

10 Anal and perianal squamous carcinomas and high-grade intraepithelial lesions exclusively associated with low-risk HPV genotypes 6 and 11 International Journal of Cancer, May 2, 2013
Cornall AM et al. - hpv 6 and 11 can occasionally be associated with high-grade lesion and anal cancer. Methods Using laser capture microdissection, anal and perianal invasive carcinomas and high-grade squamous intraepithelial lesions (HSILs) in biopsies previously associated with hpv 6 or 11 alone were isolated from tissue sections and hpv genotype tested. Results Of seven cases tested, four invasive carcinomas were positive for hpv 6 only, one invasive carcinoma was ...