Atypical glandular cells associated with increased risk of extrauterine disease
As reported in the International Journal of Gynecologic Cancer, abnormal cervical cytology (atypical glandular cells [AGC] or malignant cells [MC]) on pre-operative cervical cytology predicts extrauterine disease (OR=4.78) and high intermediate risk disease (OR=8.41) in patients with endometrial adenocarcinoma (n=563). In patients with an elevated CA-125 level, the OR for extrauterine and high intermediate risk disease was 13.3 and 5.83, respectively.
EZH2 predicts poor prognosis in cervical cancer
As reported in the International Journal of Gynecological Pathology, the expression of enhancer zeste homolog (EZH)2 is associated with clinical stage, histologic differentiation, depth of infiltration, and lymph node metastasis in patients with cervical cancer; moreover, EZH2 expression is associated with a decreased OS. Expression of EZH2 was demonstrated in 10% of normal cervical specimens, 52% of LGSIL specimens, 64% of HGSIL specimens, and 68.3% of cervical cancer specimens.
Endometrial and ovarian cancer risk increased in PCOS
Based on a meta-analysis reported in Human Reproduction Update, women with polycystic ovarian syndrome [PCOS] (n=919; 11 studies) < 54 years of age, are at increased risk for endometrial (HR = 4.05) and ovarian cancer (HR = 2.52), but not breast cancer (HR = 0.78).