EZH2 predicts poor prognosis in cervical cancer
As reported in the International Journal of Gynecological Pathology, the expression of enhancer zeste homolog (EZH)2 is associated with clinical stage, histologic differentiation, depth of infiltration, and lymph node metastasis in patients with cervical cancer; moreover, EZH2 expression is associated with a decreased OS. Expression of EZH2 was demonstrated in 10% of normal cervical specimens, 52% of LGSIL specimens, 64% of HGSIL specimens, and 68.3% of cervical cancer specimens.
Apelin levels correlate with insulin sensitivity and lipid profile in PCOS
As reported in Seizure: European Journal of Epilepsy, patients with epilepsy (n=3182) have a 3-fold increased risk for cerebral stroke. The risk was highest in the 20-39 year age group and those taking high doses of anti-epileptic medications.
Endometrial and ovarian cancer risk increased in PCOS
Based on a meta-analysis reported in Human Reproduction Update, women with polycystic ovarian syndrome [PCOS] (n=919; 11 studies) < 54 years of age, are at increased risk for endometrial (HR = 4.05) and ovarian cancer (HR = 2.52), but not breast cancer (HR = 0.78).