Atypical glandular cells associated with increased risk of extrauterine disease
As reported in the International Journal of Gynecologic Cancer, abnormal cervical cytology (atypical glandular cells [AGC] or malignant cells [MC]) on pre-operative cervical cytology predicts extrauterine disease (OR=4.78) and high intermediate risk disease (OR=8.41) in patients with endometrial adenocarcinoma (n=563). In patients with an elevated CA-125 level, the OR for extrauterine and high intermediate risk disease was 13.3 and 5.83, respectively.
Endometrial and ovarian cancer risk increased in PCOS
Based on a meta-analysis reported in Human Reproduction Update, women with polycystic ovarian syndrome [PCOS] (n=919; 11 studies) < 54 years of age, are at increased risk for endometrial (HR = 4.05) and ovarian cancer (HR = 2.52), but not breast cancer (HR = 0.78).
Apelin levels correlate with insulin sensitivity and lipid profile in PCOS
As reported in Seizure: European Journal of Epilepsy, patients with epilepsy (n=3182) have a 3-fold increased risk for cerebral stroke. The risk was highest in the 20-39 year age group and those taking high doses of anti-epileptic medications.