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Reduced expression and concomitant promoter hypermethylation of HOXA10 in endometrium from women wearing intrauterine devices
Fertility and Sterility, 11/03/09

Lu Y et al. – Prolonged IUD use may induce endometrial HOXA10 hypermethylation and reduced expression. These results suggest a possible novel mode of action for IUD, a possibility to rectify the aberrant methylation through pharmacologic means, and a possible noninvasive way for detection of aberrant methylation at HOXA10.

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