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Genetic Variation in the Progesterone Receptor and Metabolism Pathways and Hormone Therapy in Relation to Breast Cancer Risk
American Journal of Epidemiology, 10/22/09

Reding KW et al. – In an analysis combining data from 2 population–based case–control studies of postmenopausal breast cancer conducted in Washington State in 1997–1999 and 2000–2004, the authors evaluated how 51 single nucleotide polymorphisms in 7 progesterone–related genes influenced breast cancer risk. There was no appreciable association with breast cancer risk overall for any single nucleotide polymorphism. For rs2854482 in AKR1C2, carrying 1 or 2 A alleles was associated with a 2.0–fold increased breast cancer risk in EPT users but not in never users. For rs12387 in AKR1C3, the presence of 1 or 2 G alleles was associated with a 1.5–fold increased risk among EPT users but not in never users. Interpretation of these subgroup associations must await the results of similar studies conducted in other populations.

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