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See Latest ArticlesThe delicate balance between male and female sex determining pathways: potential for disruption of early steps in sexual development
International Journal of Andrology, 10/26/09
Koopman P – If either the testicular or ovarian pathway stalls in the early stages, mechanisms operate to engage the alternative pathway. For these reasons, the early steps in mammalian sexual development are vulnerable to genetic and environmental perturbation, and represent possible points of action of endocrine disrupting compounds.
Peter Koopman, 10/26/09
| Endocrine disrupting compounds are conventionally thought to interfere with hormonal pathways involved in secondary sexual differentiation of the fetus. Here, i summarize evidence that the gene regulatory pathways that lead to primary differentiation of the fetal gonads as testes or ovaries are delicate, and involve extracellular signalling steps that are also likely to be vulnerable to endocrine disruptors. Hence, I suggest that the window of sensitivity may begin much earlier than is commonly believed. |
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