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See Latest ArticlesDisruption of Tsc2 in oocytes leads to overactivation of the entire pool of primordial follicles
Molecular Human Reproduction, 10/21/09
Liu K et al. – The authors' results also indicate that deregulation of Tsc/mTOR signaling in oocytes may cause pathological conditions of the ovary such as infertility and POF.
Kui Liu, 10/21/09
| The results indicate that the suppressed mTOR signaling by Tsc1-Tsc2 complex is important to maintain the primordial follicles at a dormant state, in order to provide eggs for later use; and mTOR activity is important for activation of primordial follicles. These results are corroborated by another paper of ours: Deepak Adhikari, Wenjing Zheng, Yan Shen, Nagaraju Gorre, Tuula Hämäläinen, Austin J. Cooney, Ilpo Huhtaniemi, Zi-Jian Lan, and Kui Liu Tsc/mTORC1 signaling in oocytes governs the quiescence and activation of primordial follicles. Human Molecular Genetics, Advance Access published on October 20, 2009. doi:10.1093/hmg/ddp483 |
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