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Cytogenetic analyses of human oocytes provide new data on non-disjunction mechanisms and the origin of trisomy 16
Human Reproduction, 10/15/09

Caldes MG et al. – In the present study, the authors report the finding of a considerable frequency of aneuploidy in oocytes from young donors, with the frequency of PSSC being higher than the frequency of whole–chromosome non–disjunction. In addition, the authors report vulnerable patterns of meiotic recombination in chromosome 16 that may be at risk of leading to a non–disjunction event. This gives new data on the susceptibility of the control population to conceive a trisomic 16 embryo.

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