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Soluble Human Leukocyte Antigen-G Isoforms in Maternal Plasma in Early and Late Pregnancy
American Journal of Reproductive Immunology, 10/13/09

Rizzo R et al. – This study shows in line with other published studies that a high, detectable soluble HLA–G concentration in maternal plasma or serum is not mandatory for a successful pregnancy. This study indicates that sHLA–G1 is the interesting soluble HLA–G isoform in pre–eclampsia, and that low or undetectable levels of HLA–G5 at the end of pregnancy seem to be associated with an uncomplicated normal pregnancy, whereas in severe pre–eclampsia and possibly other pregnancy complications, such as preterm birth and IUGR, the level of HLA–G5 is higher.

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