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See Latest ArticlesTopotecan triggers apoptosis in p53-deficient cells by forcing degradation of XIAP and survivin thereby activating caspase-3 mediated Bid cleavage
Journal of Pharmacology and Experimental Therapeutics, 10/14/09
Tomicic–Christmann M et al. – The data show that p53–deficient/depleted cells are hypersensitive to TPT because they down–regulate XIAP and survivin and thus amplify the intrinsic apoptotic pathway via caspase–3–mediated Bid cleavage. Therefore, in gliomas harboring wild–type p53 TPT–based therapy might be improved by targeted down–regulation of XIAP and survivin.
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