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Prokineticin (PROK1) modulates interleukin (IL)-11 expression via prokineticin receptor (PROKR1) and the calcineurin/NFAT signalling pathway
Molecular Human Reproduction, 10/05/09
Jabbour HN et al. – Prokineticin–1 (PROK1) is a multifunctional secreted protein which signals via the G–protein coupled receptor (GPCR), PROKR1. Previous data from laboratory using a human genome survey microarray showed that PROK1–PROKR1 signalling regulates numerous genes important for establishment of early pregnancy, including the cytokine IL–11.
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