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Jabbour HN et al. – Prokineticin–1 (PROK1) is a multifunctional secreted protein which signals via the G–protein coupled receptor (GPCR), PROKR1. Previous data from laboratory using a human genome survey microarray showed that PROK1–PROKR1 signalling regulates numerous genes important for establishment of early pregnancy, including the cytokine IL–11.

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