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See Latest ArticlesAdipose tissue expandability and the early origins of PCOS
Trends in Endocrinology and Metabolism, 10/16/09
de Zegher F et al. – The most prevalent phenotypes of polycystic ovary syndrome (PCOS) are characterized by insulin resistance and androgen excess. The adipose tissue (AT) expandability hypothesis explains the development of insulin resistance in obesity and in cases of AT deficit. In line with this hypothesis, the authors propose that hyperinsulinemic androgen excess in PCOS is often underpinned by exhaustion of the capacity to expand subcutaneous AT in a metabolically safe way.
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