Ob/Gyn Medical News about Breast Neoplasms

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1. Report Shows Shift in Starting Salaries for Physicians

2. Taxane-based combinations as adjuvant chemotherapy of early breast cancer: a meta-analysis of randomized trials

3. Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer

4. 2008 Exclusive Survey—Earnings: Good news for primary care income

5. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer

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Current data of targeted therapies for the treatment of triple-negative advanced breast cancer: empiricism or evidence-based
Expert Opinion on Investigational Drugs, 10/02/09

Petrelli F et al. – Treatment of TN BC is more empirical than evidence–based. The cornerstone of treatment is chemotherapy, but in the near future, novel target agents will emerge as possible partners.

Exclusive Author Commentary
Fausto Petrelli, 10/03/09

Tre treatment of triple-receptor negative breast cancer is a challenge for medical oncologist standind the lack of a real “target” to hit. Up today none exist other than standard chemotherapy, the disease respond very well but the prognosis is however poor. Why a so chemosensitive disease retains so bad outcome? Is there a critical target useful for therapeutic purpose? Much work has been done to look for it (EGFR, VEGF, c-Kit, BRCA, DNA..) and a plethora of target therapies has been tested in this setting. We have reviewed all agents and studies available up today used in triple negative advanced breast cancer. As the readers will see this strategy is not yet winning for these unfortunately patients.

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Sinusal localization of nodal micrometastases is a prognostic factor in breast cancer
Annals of Oncology, 11/04/09 Relevance Score: 67%

Energy Intake and Risk of Postmenopausal Breast Cancer: An Expanded Analysis in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) Cohort
Cancer Epidemiology, Biomarkers & Prevention, 10/23/09 Relevance Score: 67%

Diagnosis of breast cancer in women age 40 and younger: delays in diagnosis result from underuse of genetic testing and breast imaging
The American Journal of Surgery, 10/07/09 Relevance Score: 67%

The predictive value of incidental PET/CT findings suspicious for breast cancer in women with non-breast malignancies
The American Journal of Surgery, 10/06/09 Relevance Score: 67%

A case–control study of reproductive factors associated with subtypes of breast cancer in Northeast China
Medical Oncology, 10/01/09 Relevance Score: 67%