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Marked Individual Variation in Isoflavone Metabolism After a Soy Challenge Can Modulate the Skeletal Effect of Isoflavones in Premenopausal Women
Journal of Korean Medical Science, 10/06/09
Kwak HS et al. – Serum osteocalcin concentration in the genistein high–excretors increased significantly after a challenge but did not increase in either the placebo or genistein low–excretors. An estrogenic antagonistic effect of isoflavones on bone turnover was observed in premenopausal women who are able to produce more potent metabolites.
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