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Variants of folate metabolism genes and risk of left-sided cardiac defects
Birth Defects Research, 09/25/09

Goldmuntz E et al. – The results, which are based on the largest study sample and most comprehensive assessment of the relationship between left–sided cardiac defects and folate–related genes reported to date, provide little evidence that this subset of CHDs is folate related. However, even larger studies and more comprehensive evaluations of the folate pathway genes are required to fully explore the relationship between folate and left–sided cardiac defects.

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