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See Latest ArticlesHypoxia inducible factors regulate pluripotency and proliferation in human embryonic stem cells cultured at reduced oxygen tensions
Journals of Reproduction and Fertility, 09/28/09
Houghton FD et al. – The data demonstrate that a low oxygen tension is preferential for the maintenance of a highly proliferative, pluripotent population of hES cells. While HIF–3alpha was found to regulate the expression of both HIF–1alpha and HIF–2alpha, it is HIF–2alpha which regulates hES cell pluripotency as well as proliferation under hypoxic conditions.
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