Ob/Gyn Medical News about Folic Acid Histones Methylation

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Mandatory fortification with folic acid in the United States appears to have adverse effects on histone methylation in women with pre-cancer but not in women free of pre-cancer
International Journal of Women's Health, 09/22/09

Piyathilake CJ et al. – Higher levels of Lys–9 methylation in >=CIN 2 compared to <=CIN 1 lesions suggest that higher Lys–9 methylation is associated with progression of lower grade CIN to higher grade CIN. Higher Lys–9 methylation in cervical tissues of women diagnosed with CIN 3 in the postfortification period than in pre–fortification period suggest that fortification may adversely affect histone methylation in already initiated cells. Lower Lys–9 methylation in normal/reactive cervical cells of women free of CIN in the post–fortification period than pre–fortification on the other hand suggests that fortification is likely to protect against initiation of carcinogenic process in the cervix. These results suggest that mandatory fortification with folic acid in the US seems to have different effects on cancer depending on the stage of carcinogenesis. Because this is the first study to report folic acid fortification–associated differences in histone methylation and because of the limitations inherent to the approach the authors have taken to demonstrate these differences, validation of the results in other study populations or with other techniques for assessing histone methylation is necessary.

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