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Soy isoflavone supplementation and bone mineral density in menopausal women: a 2-y multicenter clinical trial
American Journal of Clinical Nutrition, 09/17/09

Wong WW et al. – Daily supplementation with 120 mg soy hypocotyl isoflavones reduces whole–body bone loss but does not slow bone loss at common fracture sites in healthy postmenopausal women.

Methods

A multicenter, randomized, double–blind, placebo–controlled 24–mo trial was conducted to assess the effects of daily supplementation with 80 or 120 mg of soy hypocotyl aglycone isoflavones plus calcium and vitamin D on bone changes in 403 postmenopausal women.
Study subjects were tested annually and changes in whole–body and regional bone mineral density (BMD), bone mineral content (BMC), and T scores were assessed.
Changes in serum biochemical markers of bone metabolism were also assessed.

Results

After study site, soy intake, and pretreatment values were controlled for, subjects receiving a daily supplement with 120 mg soy isoflavones had a statistically significant smaller reduction in whole–body BMD than did the placebo group both at 1 y and at 2 y of treatment.
Smaller decreases in whole–body BMD T score were observed among this group of women at 1 y but not at 2 y of treatment.
When compared with the placebo, soy isoflavone supplementation had no effect on changes in regional BMD, BMC, T scores, or biochemical markers of bone metabolism.

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