Ob/Gyn Medical News about ibandronate; postmenopausal women; gastrointestinal irritability

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Gastrointestinal tolerability with ibandronate after previous weekly bisphosphonate treatment
Clinical Interventions in Aging, 09/09/09

Derman R et al. – Postmenopausal women with GI irritability with daily or weekly BPs experienced improvement in symptoms with extended dosing monthly or quarterly ibandronate compared with baseline.

Methods

Two open–label trials: PRIOR and CURRENT.
In PRIOR, women who had discontinued daily or weekly BP treatment due to GI intolerance received monthly oral or quarterly IV ibandronate for 12 months.
The CURRENT subanalysis included women receiving weekly BP treatment who switched to monthly oral ibandronate for six months.
GI symptom severity and frequency were assessed using the Osteoporosis Patient Satisfaction Questionnaire.

Results

In PRIOR, mean GI tolerability scores increased significantly at month 1 from screening for both treatment groups.
Most patients reported improvement in GI symptom severity and frequency from baseline at all post–screening assessments (>90% at Month 10).
In the CURRENT subanalysis >60% of patients reported improvements in heartburn or acid reflux and >70% indicated improvement in other stomach upset at month 6.

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